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Untargeted Proteomic Profiling Identifies Candidate Biomarkers for Early Detection of Cardiovascular Disease and Mortality

Untargeted Proteomic Profiling Identifies Candidate Biomarkers for Early Detection of Cardiovascular Disease and Mortality

Chybowska AD, Vernardis S, McCartney DL, Mur J, Robertson J, Smith HM, Campbell A, Drake C, Grant H, Adkin P, White M, Messner CB, Grauslys A, Andrejev S, Brigden C, Porteous DJ, Hayward C, Price JF, Evans KL, Zelezniak A, Ralser M and Marioni RE

In 8,343 participants followed for up to 17 years, the study links high-abundance serum proteins with cardiovascular outcomes and mortality and develops a proteomic risk score. The work was carried out with Eliptica’s involvement and demonstrates how population-scale serum proteomics can support cardiovascular risk stratification and biomarker discovery.

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