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An INS-1 832/13 β-Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose-Stimulated Insulin Secretion

An INS-1 832/13 β-Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose-Stimulated Insulin Secretion

Stremmel N, Lemke O, Textoris-Taube K, Ludwig D, Mülleder M, Muenzner J and Ralser M

Led by Eliptica CSO and co-founder Markus Ralser, the study profiles INS-1 β cells and reveals rapid regulation of fatty-acid biosynthesis in response to glucose stimulation. The work shows how quantitative proteomics can capture dynamic biological responses, reinforcing the value of protein measurements as a direct readout of functional physiology and disease-relevant biology.

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