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A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness

A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness

Jakobson CM, Hartl J, Trébulle P, Mülleder M, Jarosz DF and Ralser M

Led by Eliptica CSO and co-founder Markus Ralser, the study links genetic variation to proteome diversity and fitness, providing a systems-level view of how sequence differences propagate through protein abundance to phenotype. The work demonstrates the analytical power of large-scale quantitative proteomics for understanding complex biological systems.

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